Dataset Information
GNPS Antiviral Euphorbia dendroides extract and fractions (plants)
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap XL
ORGANISM(S): Euphorbia Dendroides (ncbitaxon:38845)
SUBMITTER: Litaudon / Paolini
PROVIDER: MSV000080502 | GNPS | Tue Jan 24 13:25:00 GMT 2017
REPOSITORIES: GNPS
Publications
Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.
Journal of natural products 20180302 4
It is a common problem in natural product therapeutic lead discovery programs that despite good bioassay results in the initial extract, the active compound(s) may not be isolated during subsequent bioassay-guided purification. Herein, we present the concept of bioactive molecular networking to find candidate active molecules directly from fractionated bioactive extracts. By employing tandem mass spectrometry, it is possible to accelerate the dereplication of molecules using molecular networking ...[more]
