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GNPS - ImmunosuppressantStudy_Skin_mzXML_PUBLIC

ABSTRACT: data from human skin samples (50% ethanol soaked cotton swabs used for sampling) from a clinical cohort undergoing immunosuppressant therapy following organ transplant.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Alan Jarmusch Pieter Dorrestein Shirley M. Tsunoda

PROVIDER: MSV000081548 | GNPS |

REPOSITORIES: GNPS

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Publications

Initial Development toward Non-Invasive Drug Monitoring via Untargeted Mass Spectrometric Analysis of Human Skin.

Jarmusch Alan K AK Elijah Emmanuel O EO Vargas Fernando F Bouslimani Amina A da Silva Ricardo R RR Ernst Madeleine M Wang Mingxun M Del Rosario Krizia K KK Dorrestein Pieter C PC Tsunoda Shirley M SM

Analytical chemistry 20190610 13

Drug monitoring is crucial for providing accurate and effective care; however, current methods (e.g., blood draws) are inconvenient and unpleasant. We aim to develop a non-invasive method for the detection and monitoring of drugs via human skin. The initial development toward this aim required information about which drugs, taken orally, can be detected via the skin. Untargeted liquid chromatography-mass spectrometry (LC-MS) was used as it was unclear if drugs, known drug metabolites, or other t ...[more]

PMID: 31074958

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ImmunosuppressantStudy_Skin_mzXML_PUBLIC

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