Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS ApoEKO_IHC_mousegut

ABSTRACT: ApoE knockout mice were exposed to intermittent hypoxia and hypercapnia (treatment) or room air (controls). Perturbations in the gut microbiome were profiled longitudinally using LC-MS/MS to study the impact of treatment on the gut metabolome.

INSTRUMENT(S): Q-Exactive

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Gabriel Haddad

PROVIDER: MSV000082972 | GNPS |

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Circadian_IHC_ApoE_KO_mice_acute_study

Project description:ApoE knockout mice were exposed to intermittent hypoxia and hypercapnia (treatment) or room air (controls). Perturbations in the gut microbiome were profiled longitudinally using LC-MS/MS to study the impact of treatment on the gut metabolome over the course of the day. Samples were collected after 6 days of exposure to conditions. Samples were collected every 4 hours for 24hrs (6 timepoints) to examine circadian rhythm dynamics.

2020-01-27 | MSV000084847 | MassIVE

GNPS - Circadian_IHC_ApoE_KO_mice_acute_study

2020-01-27 | MSV000084847 | GNPS

Epigenetic profiling of aorta macrophages of mice exposed to intermittent hypoxia (CD11ME)

Project description:ChIP-seq targeting H3K9ac and H3K27me3 histone modifications was carried out on macrophages isolated from aortas of mice exposed to intermittent hypoxia or room air conditions.

2017-06-12 | GSE86851 | GEO

GNPS ApoEKO_IH_IC_mousegut

Project description:ApoE knockout mice were either exposed to hypoxia, or hypercapnia, or both or kept in room air (controls) and fecal samples were collected longitudinally. Impact of treatments were studied using non-targeted LC-MS/MS data

| MSV000082973 | GNPS

Temporal effects of intermittent- and sustained hypoxia on gene expression patterns in rat lungs

Project description:Time-course gene expression profiles were obtained from lung tissues of the rats treated with room air, intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days using CodeLink microarrays. Using a systems biology approach, we observed that two different mechanisms are involved in the lung responses to IH and SH: IH leads to increased G-protein coupled signaling-, ion transport-, neuronal- and steroid hormone receptor activities; whereas SH causes increased blood vessel morphogenesis and immune responses. Our results provide insight into molecular mechanisms underlying IH and SH. Keywords: gene expression array-based, count rats were treated with intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days; rats treated with room air were used as controls; gene expression profiles were obtained from these rats

2008-12-17 | E-GEOD-8705 | biostudies-arrayexpress

Chronic Intermittent Hypoxia Increases Alveolar Surface Area in Adult Mice

Project description:Obstructive sleep apnea (OSA) leads to increased cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O2 profile in patients with OSA. We exposed adult C57BL/6J mice to 3 months of IH with an FIO2 nadir of 5%, 60 times/hr during the 12hr light phase. Control mice were exposed to room air.

2010-12-31 | GSE21409 | GEO

Temporal effects of intermittent- and sustained hypoxia on gene expression patterns in rat lungs

2008-12-18 | GSE8705 | GEO

Expression data from human A549 cells and exosomes under room air (RA) or intermittent hypoxia (IH)

Project description:Expression data from human A549 cells and exosomes under room air (RA) or intermittent hypoxia (IH)

| PRJNA750503 | ENA

Transcription profiling of mouse liver to identify the effect of intermittent hypoxia on gene expression in the liver of ob/ob mice

Project description:All animals were kept in a controlled environment (22-24 °C with a 12 h : 12 h light : dark cycle; lights on at 09.00) on a standard chow diet with free access to water. Five ob/ob mice (sample_ids GSM32865-GSM32869) were placed in the intermittent hypoxia (IH) chamber and subjected to IH for 12 consecutive weeks and compared to pair-fed control exposed to intermittent room (IA) air for 12 weeks in identical chambers (n = 5, sample_ids GSM32860-GSM32864). The IH and IA states were induced during the light phase alternating with 12 h of constant room air during the dark phase. The IH and IA groups were weight-matched daily during the experiment by varying food intake. Weight-matching was conducted in pairs. The signal intensity fluorescent images produced during samples hybridizations to Affymetrix GeneChip were read using the Agilent Gene Array Scanner and converted into GeneChip Cell files (CEL) using MAS 5.0 software (Affymetrix, Santa Clara, CA). Gene expression values were generated form CEL files using Robust Microarray Analysis (RMA, Bioconductor affy package). Briefly, the rma module of this package was used for background correction, across array normalization, and extraction of the probe level data. Ref: Irizarry R, Gautier L, and Cope L, An R package for analyses of Affymetrix oligonucleotide arrays. The Analysis of Gene Expression Data: Methods and Software, ed. G Parmigiani,ES Garrett, RA Irizarry,and SL Zeger. 2003, New York: Springer

2007-11-01 | E-GEOD-1873 | biostudies-arrayexpress

The effect of intermittent hypoxia on gene expression in the liver of ob/ob mice

2004-10-27 | GSE1873 | GEO