Dataset Information
GNPS - Chemotyping of leaf and stem of 5 species of the genus Piper
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: MSV000083277MSV000083276
INSTRUMENT(S): Q Exactive
ORGANISM(S): Piper Auritum (ncbitaxon:130385) Piper Nigrum (ncbitaxon:13216) Piper Sarmentosum (ncbitaxon:405319) Piper Betle (ncbitaxon:13217) Piper Methysticum (ncbitaxon:130404)
SUBMITTER: 
Jing-Ke Weng
PROVIDER: MSV000083274 | GNPS | Sat Dec 22 06:30:00 GMT 2018
REPOSITORIES: GNPS
Publications
The biosynthetic origin of psychoactive kavalactones in kava.
Nature plants 20190722 8
Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct from those of conventional psychiatric drugs. However, an unknown biosynthetic machinery and difficulty in chemical synthesis hinder the therapeutic use of kavalactones. In addition, kava also ...[more]
