Metabolomics

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GNPS Metabolomics analysis of 180 cancer cell lines

ABSTRACT: Metabolome analysis of 180 cancer cell lines. Intracellular extracts. Flow injection analysis - TOF (negative mode, no LC). Sample description is included in Metadata_File_CellLines.txt

INSTRUMENT(S): 6550 Quadrupole Time-of-Flight

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Nicola Zamboni  

PROVIDER: MSV000087155 | GNPS | Sun Apr 04 13:38:00 BST 2021

REPOSITORIES: GNPS

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A functional analysis of 180 cancer cell lines reveals conserved intrinsic metabolic programs.

Cherkaoui Sarah S   Durot Stephan S   Bradley Jenna J   Critchlow Susan S   Dubuis Sebastien S   Masiero Mauro Miguel MM   Wegmann Rebekka R   Snijder Berend B   Othman Alaa A   Bendtsen Claus C   Zamboni Nicola N  

Molecular systems biology 20221101 11

Cancer cells reprogram their metabolism to support growth and invasion. While previous work has highlighted how single altered reactions and pathways can drive tumorigenesis, it remains unclear how individual changes propagate at the network level and eventually determine global metabolic activity. To characterize the metabolic lifestyle of cancer cells across pathways and genotypes, we profiled the intracellular metabolome of 180 pan-cancer cell lines grown in identical conditions. For each cel  ...[more]

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