Metabolomics

Dataset Information

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GNPS - Dataset Creation from GNPS Molcular Networking - 89895d4507c84596a6a01685bfd8acd4

ABSTRACT: Molecular Networking of fungal culture extracts from T. erinacei analyzed by LC-MS in positive ion mode

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Trichophyton Erinacei (ncbitaxon:523106)

SUBMITTER: Jesper Larsen  

PROVIDER: MSV000087335 | GNPS | Thu Apr 29 01:44:00 BST 2021

REPOSITORIES: GNPS

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Publications

Emergence of methicillin resistance predates the clinical use of antibiotics.

Larsen Jesper J   Raisen Claire L CL   Ba Xiaoliang X   Sadgrove Nicholas J NJ   Padilla-González Guillermo F GF   Simmonds Monique S J MSJ   Loncaric Igor I   Kerschner Heidrun H   Apfalter Petra P   Hartl Rainer R   Deplano Ariane A   Vandendriessche Stien S   Černá Bolfíková Barbora B   Hulva Pavel P   Arendrup Maiken C MC   Hare Rasmus K RK   Barnadas Céline C   Stegger Marc M   Sieber Raphael N RN   Skov Robert L RL   Petersen Andreas A   Angen Øystein Ø   Rasmussen Sophie L SL   Espinosa-Gongora Carmen C   Aarestrup Frank M FM   Lindholm Laura J LJ   Nykäsenoja Suvi M SM   Laurent Frederic F   Becker Karsten K   Walther Birgit B   Kehrenberg Corinna C   Cuny Christiane C   Layer Franziska F   Werner Guido G   Witte Wolfgang W   Stamm Ivonne I   Moroni Paolo P   Jørgensen Hannah J HJ   de Lencastre Hermínia H   Cercenado Emilia E   García-Garrote Fernando F   Börjesson Stefan S   Hæggman Sara S   Perreten Vincent V   Teale Christopher J CJ   Waller Andrew S AS   Pichon Bruno B   Curran Martin D MD   Ellington Matthew J MJ   Welch John J JJ   Peacock Sharon J SJ   Seilly David J DJ   Morgan Fiona J E FJE   Parkhill Julian J   Hadjirin Nazreen F NF   Lindsay Jodi A JA   Holden Matthew T G MTG   Edwards Giles F GF   Foster Geoffrey G   Paterson Gavin K GK   Didelot Xavier X   Holmes Mark A MA   Harrison Ewan M EM   Larsen Anders R AR  

Nature 20220105 7895

The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics<sup>1</sup>. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus-a notorious human pathogen-appeared in European hedgehogs in the pre-antibiotic era. Subsequently,  ...[more]

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