Dataset Information
GNPS Molecular Networking Example Dataset - Burkholderia LB
Ontology highlight
ABSTRACT:
INSTRUMENT(S): impact II
ORGANISM(S): Burkholderia Sp. (ncbitaxon:36773)
SUBMITTER: 
Neha Garg
PROVIDER: MSV000087997 | GNPS | Tue Aug 17 14:33:00 BST 2021
REPOSITORIES: GNPS
Publications
Molecular networking-based strategies in mass spectrometry coupled with in silico dereplication of peptidic natural products and gene cluster analysis.
Methods in enzymology 20211016
Peptidic natural products (PNPs) are valuable sources for drug development as they are often associated with desirable bioactivities. Chemoenzymatic approaches coupled with description of structure-activity relationships have enabled the production of analogs to PNPs such as daptomycin and vancomycin which exhibit optimized bioactivities. The natural promiscuity of biosynthetic enzymes allows the producer organism to generate various analogs potentially serving as multiple hits for one target or ...[more]
