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GNPS - Self-Resistance Mechanism mediated by N-acetyltransferase PamZ

ABSTRACT: Self-resistance mechanism mediated by N-acetyltransferase PamZ by deactivation of own antibacterial agent paenilamicin in Paenibacillus larvae, the causative agent of the honey bee disease American Foulbrood.

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Paenibacillus Larvae Subsp. Larvae 04-309 (ncbitaxon:697284)

SUBMITTER: Roderich Suessmuth

PROVIDER: MSV000088695 | GNPS | Tue Jan 18 06:52:00 GMT 2022

REPOSITORIES: GNPS

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Publications

Molecular basis of antibiotic self-resistance in a bee larvae pathogen.

Dang Tam T Loll Bernhard B Müller Sebastian S Skobalj Ranko R Ebeling Julia J Bulatov Timur T Gensel Sebastian S Göbel Josefine J Wahl Markus C MC Genersch Elke E Mainz Andi A Süssmuth Roderich D RD

Nature communications 20220429 1

Paenibacillus larvae, the causative agent of the devastating honey-bee disease American Foulbrood, produces the cationic polyketide-peptide hybrid paenilamicin that displays antibacterial and antifungal activity. Its biosynthetic gene cluster contains a gene coding for the N-acetyltransferase PamZ. We show that PamZ acts as self-resistance factor in Paenibacillus larvae by deactivation of paenilamicin. Using tandem mass spectrometry, nuclear magnetic resonance spectroscopy and synthetic diastere ...[more]

PMID: 35487884

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