GNPS - Metabolic landscape of the male mouse gut identifies different niches determined by microbial activities
Ontology highlight
ABSTRACT:
INSTRUMENT(S): 6550 iFunnel Q-TOF LC/MS
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Prof. Dr. Uwe Sauer
PROVIDER: MSV000091478 | GNPS | Mon Mar 13 10:47:00 GMT 2023
REPOSITORIES: GNPS
Publications
Metabolic landscape of the male mouse gut identifies different niches determined by microbial activities.
Meier Karin H U KHU Trouillon Julian J Li Hai H Lang Melanie M Fuhrer Tobias T Zamboni Nicola N Sunagawa Shinichi S Macpherson Andrew J AJ Sauer Uwe U
Nature metabolism 20230522 6
Distinct niches of the mammalian gut are populated by diverse microbiota, but the contribution of spatial variation to intestinal metabolism remains unclear. Here we present a map of the longitudinal metabolome along the gut of healthy colonized and germ-free male mice. With this map, we reveal a general shift from amino acids in the small intestine to organic acids, vitamins and nucleotides in the large intestine. We compare the metabolic landscapes in colonized versus germ-free mice to disenta ...[more]
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