Dataset Information

GNPS - Quantifying Cell Heterogeneity and Subpopulations Using Single Cell Metabolomics

ABSTRACT: We combined the Single-probe single cell MS(SCMS) experimental technique with a bioinformatics software package, SinCHet-MS (Single Cell Heterogeneity for Mass Spectrometry), to characterize changes of tumor heterogeneity, quantify cell subpopulations, and prioritize the metabolite biomarkers of each subpopulation.

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Zhibo Yang

PROVIDER: MSV000092178 | GNPS | Thu Jun 15 10:45:00 BST 2023

REPOSITORIES: GNPS

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Publications

Quantifying Cell Heterogeneity and Subpopulations Using Single Cell Metabolomics.

Liu Renmeng R Li Jiannong J Lan Yunpeng Y Nguyen Tra D TD Chen Y Ann YA Yang Zhibo Z

Analytical chemistry 20230428 18

Mass spectrometry (MS) has become an indispensable tool for metabolomics studies. However, due to the lack of applicable experimental platforms, suitable algorithm, software, and quantitative analyses of cell heterogeneity and subpopulations, investigating global metabolomics profiling at the single cell level remains challenging. We combined the Single-probe single cell MS (SCMS) experimental technique with a bioinformatics software package, SinCHet-MS (Single Cell Heterogeneity for Mass Spectr ...[more]

PMID: 37115510

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