Metabolomics

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GNPS - Obesity and GDM associated changes in placental and maternal blood lipidomic profile: evidence for sexual dimorphism

ABSTRACT: This study assesses fatty acid composition of lipids in matched maternal plasma and placental tissue from lean, obese and gestational diabetes (GDM) women stratified by fetal sex. Obesity and GDM are associated with adverse pregnancy outcomes and program the offspring for cardiometabolic disease in a sexually dimorphic manner. We collected maternal plasma and placental villous tissue following elective cesarean section at term from women who were lean (pre-pregnancy BMI 18.5-24.9), Obese (BMI>30) and type A2 GDM (matched to obese BMI) with either a male or female fetus (n=4 each group). Lipids were extracted and fatty acid composition of different lipid classes were analyzed by LC-MS/MS to find significant changes in GDM vs Obese, GDM vs Lean, and Obese vs Lean.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Kristin Burnum-Johnson  

PROVIDER: MSV000094962 | GNPS | Sun Jun 09 19:27:00 BST 2024

REPOSITORIES: GNPS

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Sexual dimorphism in lipidomic changes in maternal blood and placenta associated with obesity and gestational diabetes: A discovery study.

Kadam Leena L   Veličković Marija M   Stratton Kelly K   Nicora Carrie D CD   Kyle Jennifer E JE   Wang Eric E   Monroe Matthew E ME   Bramer Lisa M LM   Myatt Leslie L   Burnum-Johnson Kristin E KE  

Placenta 20241204

<h4>Introduction</h4>The placenta uses lipids and other nutrients to support its own metabolism hence impacting the type and amount of these substrates available to the growing fetus. Maternal obesity and gestational diabetes (GDM) can disrupt placental lipid metabolism and thus lead to altered fetal growth contributing to adverse pregnancy outcomes and developmentally programing the offspring for disease in later life. Understanding obesity and GDM driven changes in placental lipid metabolism i  ...[more]

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