Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens Escherichia Coli Mus Musculus
SUBMITTER: Shan Li
PROVIDER: PXD019062 | iProX | Fri Jun 05 00:00:00 BST 2020
REPOSITORIES: iProX
Meng Kun K Zhuang Xiaohui X Peng Ting T Hu Shufan S Yang Jin J Wang Zhen Z Fu Jiaqi J Xue Juan J Pan Xing X Lv Jun J Liu Xiaoyun X Shao Feng F Li Shan S
Communications biology 20200605 1
Salmonella enterica serovar Typhimurium, an intracellular Gram-negative bacterial pathogen, employs two type III secretion systems to deliver virulence effector proteins to host cells. One such effector, SseK3, is a Golgi-targeting arginine GlcNAc transferase. Here, we show that SseK3 colocalizes with cis-Golgi via lipid binding. Arg-GlcNAc-omics profiling reveals that SseK3 modifies Rab1 and some phylogenetically related Rab GTPases. These modifications are dependent on C-termini of Rabs but in ...[more]