Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

1 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Urinary system damage induced by ketamine

ABSTRACT: Proteomic analysis exploring the mechanism of bladder fibrosis induced by ketamine in rat model

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Zhengyan Tang

PROVIDER: PXD020596 | iProX | Mon Jul 27 00:00:00 BST 2020

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Similar Datasets

The transcriptomic analysis of bladder tissue in a rat model of ketamine-induced bladder fibrosis

Project description:The transcriptomic analysis of bladder tissue in a rat model of ketamine-induced bladder fibrosis

| PRJNA784574 | ENA

Gene activity induced by denervation in the rat urinary bladder

Project description:Gene activity induced by denervation in the rat urinary bladder

| PRJNA412993 | ENA

Gene activity induced by denervation in the rat urinary bladder [miRNA]

Project description:Gene activity induced by denervation in the rat urinary bladder [miRNA]

| PRJNA412999 | ENA

Gene activity induced by denervation in the rat urinary bladder [mRNA]

Project description:Gene activity induced by denervation in the rat urinary bladder [mRNA]

| PRJNA413000 | ENA

Urinary bladder in F344 rats: Control vs dimethylarsinic acid-induced tumors

Project description:The gene expression profling between non-treated urinary bladder epithelium (Control) and dimethylarsinic acid-induced urinary bladder tumors of F344 male rats.

2023-08-09 | GSE207973 | GEO

Urinary bladder post-spinal cord injury: time-points

Project description:Previously, we demonstrated using a rat model of spinal cord injury (SCI) that bladder wall tissue compliance significantly increased within the first 2 weeks following injury. In order to explore the potential molecular-level mechanisms of this event, the present study quantified molecules pertinent to bladder tissue remodeling and changes in mechanical properties. An initial gene array analysis followed by real-time qPCR revealed that the message levels for tropoelastin and lysyl oxidase were as high as 8-fold in SCI rats compared to normal. Furthermore, both the message and protein levels of TGF-beta1 and IGF-1, known stimulators of elastin synthesis, in SCI rat bladders were significantly higher compared to those of normal rats. Taken together, it can be speculated that functional changes of the bladder associated with SCI induce release of select growth factors, which, in turn, stimulate elastogenesis that lead to alteration of biomechanical properties of the wall tissue.

2008-12-25 | GSE14096 | GEO

Renal fibrosis mRNA classifier: validation in experimental lithium-induced interstitial fibrosis in the rat kidney

Project description:Metzincins and related genes (MARGS) play important roles in ECM remodeling in fibrotic conditions. In this investigation, gene expression was examined in a rat model to investigate whether the previously described MARGS based fibrosis classifier had diagnostic value in an experimental rat model of lithium-induced renal fibrosis

2017-02-08 | GSE83610 | GEO

Gene expression evaluation of urinary bladder in mouse model of long-term ketamine injection

Project description:The aim of this cDNA array study is to search for advanced markers related to the pathogenesis of ketamine-induced cystitis. The result revealed a number of gene expressions involved in chronic wound healing response and collagen accumulation, which were closely related to fibrosis progression in the connective tissue of mice urinary bladder.

2016-05-01 | GSE68539 | GEO

DEN-induced rat model reproduces key features of human hepatocellular carcinoma

Project description:Using RNA-seq analysis, we study a DEN-induced HCC rat model during fibrosis progression and HCC development with special focus on liver inflammatory microenvironment. RNA-seq results show that DEN-induced liver tumors in rat model share remarkable molecular characteristics with human HCC, especially with HCC associated with high proliferation. In conclusion, our study provides detailed insight into the hepatocarcinogenesis in a commonly used model of HCC, facilitating the future use of this model for preclinical testing.

2021-10-08 | GSE182860 | GEO

Diffrential expression of urinary bladder cells microRNAs ( miRs) in cyclophosphamide induced cystitis

Project description:During cyclophosphamide (CYP) induced ctstitis progression differential expression of microRNAs (miRs) play a role in urinary bladder inflammation and detrusor function. We identified eight UBs miRs that are known to be involved in various other bladder pathologies which exhibited altered expression in CYP mice and e predicted to have a role in inflammation and smooth muscle function (miR-34c-5p, -34b-3p, -212-3p, -449a-5p, -21a-3p, -376b-3p, -376b-5p and -409-5p).

2023-09-18 | GSE243239 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data