Dataset Information
The TMT-based quantitative proteomics of 5×FAD_Usp25 knockout mouse
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Xin Wang
PROVIDER: PXD021637 | iProX | Tue Sep 22 00:00:00 BST 2020
REPOSITORIES: iProX
Publications
Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25.
Science advances 20210101 1
Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer's disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in combined murine DS-AD models. Overexpression of <i>USP25</i>, a deubiquitinating enzyme encoded by chromosome 21, results in microglial activation and induces synaptic and cognitive deficits, whereas gen ...[more]
