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Comparison of Salmonella proteome between different serovars

ABSTRACT: This study compares the proteome of Salmonella enterica serovars Typhimurium, Typhi, Enteritidis, Paratyphi A, etc. under the SPI-1- and SPI-2-inducing growth conditions.

ORGANISM(S): Salmonella Sp. Wt

SUBMITTER: ChengHsun Chiu

PROVIDER: PXD022254 | iProX | Fri Oct 30 00:00:00 GMT 2020

REPOSITORIES: iProX

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"Pseudo-pseudogenes" in bacterial genomes: Proteogenomics reveals a wide but low protein expression of pseudogenes in Salmonella enterica.

Feng Ye Y Wang Zeyu Z Chien Kun-Yi KY Chen Hsiu-Ling HL Liang Yi-Hua YH Hua Xiaoting X Chiu Cheng-Hsun CH

Nucleic acids research 20220501 9

Pseudogenes (genes disrupted by frameshift or in-frame stop codons) are ubiquitously present in the bacterial genome and considered as nonfunctional fossil. Here, we used RNA-seq and mass-spectrometry technologies to measure the transcriptomes and proteomes of Salmonella enterica serovars Paratyphi A and Typhi. All pseudogenes' mRNA sequences remained disrupted, and were present at comparable levels to their intact homologs. At the protein level, however, 101 out of 161 pseudogenes suggested suc ...[more]

PMID: 35489061

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