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Diclofenac Re-sensitizes Methicillin-resistant Staphylococcus aureus to β-lactam Antibiotics and Prevents Implant Infections

ABSTRACT: Quantitative proteomic analyses were performed on proteome extracts of the different MRSA ATCC 43300 samples.

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Bing Yue

PROVIDER: PXD023055 | iProX | Fri Dec 11 00:00:00 GMT 2020

REPOSITORIES: iProX

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Diclofenac Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactams and Prevents Implant Infections.

Zhang Shutao S Qu Xinhua X Tang Haozheng H Wang You Y Yang Hongtao H Yuan Weien W Yue Bing B

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210503 13

Implant infections caused by methicillin-resistant Staphylococcus aureus (MRSA) can cause major complications during the perioperative period. Diclofenac, one of the most widely used nonsteroidal anti-inflammatory drugs, is often used to relieve pain and inflammation. In this study, it is found that high-dose diclofenac can inhibit the growth of MRSA, and does not easily induce drug-resistant mutations after continuous passage. However, low-doses diclofenac can resensitize bacteria to ...[more]

PMID: 34258168

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