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Phosphoproteomics of a mouse model of dilated cardiomyopathy

ABSTRACT: Global quantitative phosphoproteomics was performed in Cypher knockout and wild-type mice with PKA stimulation

ORGANISM(S): Mus Musculus

SUBMITTER: Xiaogang Guo

PROVIDER: PXD029026 | iProX | Sun Oct 10 00:00:00 BST 2021

REPOSITORIES: iProX

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Phosphoproteomic Analysis Reveals Downstream PKA Effectors of AKAP Cypher/ZASP in the Pathogenesis of Dilated Cardiomyopathy.

Lv Jialan J Pan Zhicheng Z Chen Jian J Xu Rui R Wang Dongfei D Huang Jiaqi J Dong Yang Y Jiang Jing J Yin Xiang X Cheng Hongqiang H Guo Xiaogang X

Frontiers in cardiovascular medicine 20211213

<b>Background:</b> Dilated cardiomyopathy (DCM) is a major cause of heart failure worldwide. The Z-line protein Cypher/Z-band alternatively spliced PDZ-motif protein (ZASP) is closely associated with DCM, both clinically and in animal models. Our earlier work revealed Cypher/ZASP as a PKA-anchoring protein (AKAP) that tethers PKA to phosphorylate target substrates. However, the downstream PKA effectors regulated by AKAP Cypher/ZASP and their relevance to DCM remain largely unknown. <b>Methods an ...[more]

PMID: 34966794

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