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Quantitative chemoproteomic profiling of protein crosslinks induced by methylglyoxal

ABSTRACT: Quantitative chemoproteomic profiling of protein crosslinks induced by methylglyoxal

ORGANISM(S): Homo Sapiens Mus Musculus

SUBMITTER: Chu Wang

PROVIDER: PXD030688 | iProX | Mon Jan 03 00:00:00 GMT 2022

REPOSITORIES: iProX

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Quantitative Chemoproteomic Profiling of Protein Cross-Links Induced by Methylglyoxal.

Chen Xuemin X Liu Yuan Y Kong Linghao L Wen Ziyang Z Wang Weize W Wang Chu C

ACS chemical biology 20220707 8

Methylglyoxal (MGO) is a highly reactive metabolite mainly formed as a byproduct of glycolysis. Elevated MGO has been considered as a risk factor for several diseases including diabetes and neurodegeneration. While MGO modifications on proteins were globally profiled, the cross-links between proteins induced by MGO in proteomes are unexplored to date. Here, we reported a quantitative chemoproteomic platform based on mass shifts that enables identification of events of protein cross-links induced ...[more]

PMID: 35797239

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