Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia Coli
SUBMITTER: Bill DeGrado
PROVIDER: PXD030722 | iProX | Wed Jan 05 00:00:00 GMT 2022
REPOSITORIES: iProX
Belsare Ketaki D KD Wu Haifan H Mondal Dibyendu D Bond Annalise A Castillo Erika E Jin Jia J Jo Hyunil H Roush Addison E AE Pilla Kala Bharath KB Sali Andrej A Condello Carlo C DeGrado William F WF
Proceedings of the National Academy of Sciences of the United States of America 20220201 5
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane receptor of the immunoglobulin superfamily that is secreted in a soluble (sTREM2) form. Mutations in TREM2 have been linked to increased risk of Alzheimer's disease (AD). A prominent neuropathological component of AD is deposition of the amyloid-β (Aβ) into plaques, particularly Aβ40 and Aβ42. While the membrane-bound form of TREM2 is known to facilitate uptake of Aβ fibrils and the polarization of microglial ...[more]