Evaluation of Acquired Antibiotic Resistance in Klebsiella pneumoniae Exposed to Short-Term Simulated Microgravity and Background Antibiotic Exposure

ABSTRACT: Space flight missions last for a long time so bacterial infection during missions is considered a potential risk for astronauts. Studies of bacterial antibiotic resistance under spaceflight and simulated microgravity (SMG) have shown contrary results. To better understand the antibiotic stress resistance of K. pneumoniae in the microgravity environment, the original strain of K. pneumoniae (CGMCC 1.839), designated the KPO strain, was cultured under SMG conditions combined with background antibiotic exposure (SMGA) as the experimental group, while the control group was cultured in a NG environment without antibiotic exposure. After 20 cycles of incubation, the growth rate, antibiotic susceptibility, genomic , transcriptomic, and proteomic tests were conducted on the experimental and control groups designated the SMGA and NG strains, respectively.

ORGANISM(S): Klebsiella Pneumoniae Subsp. Pneumoniae Kpnih1

SUBMITTER: Junfeng Wang  

PROVIDER: PXD030787 | iProX | Thu Jan 06 00:00:00 GMT 2022

REPOSITORIES: iProX