Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy
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ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Rui Liu
PROVIDER: PXD031209 | iProX | Tue Jan 25 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy.
Li Jingyi J Zhang Tao T Ren Tao T Liao Xiaoyu X Hao Yilong Y Lim Je Sun JS Lee Jong-Ho JH Li Mi M Shao Jichun J Liu Rui R
Nature communications 20220304 1
Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, a ubiquitous degradation/recycling system in eukaryotic cells, renders cells tolerant to multiple stressors. However, the mechanisms underlying autophagy initiation upon hypoxia remains unclear. Here we show that protein arginine methyltransferase 5 (PRMT5) catalyzes symmetrical dimethylation of the autophagy initiation protein ULK1 at arginine 170 (R170me2s), a modification removed by lysine demethylase 5C (KD ...[more]
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