OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Liyu Huang
PROVIDER: PXD031307 | iProX | Fri Jan 28 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR.
Fu Xuhong X Zhao Junjie J Yu Guopeng G Zhang Xiaomin X Sun Jie J Li Lingmeng L Yin Jingyi J Niu Yinan Y Ren Shancheng S Zhu Yasheng Y Xu Bin B Huang Liyu L
Communications biology 20220301 1
Ovarian tumor (OTU) subfamily deubiquitinases are involved in various cellular processes, such as inflammation, ferroptosis and tumorigenesis; however, their pathological roles in prostate cancer (PCa) remain largely unexplored. In this study, we observed that several OTU members displayed genomic amplification in PCa, among which ovarian tumor deubiquitinase 6A (OTUD6A) amplified in the top around 15-20%. Further clinical investigation showed that the OTUD6A protein was highly expressed in pros ...[more]
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