Proteome analysis of Chaetomium cochliodes SD-280
Ontology highlight
ABSTRACT:
ORGANISM(S): Chaetomium Globosum
SUBMITTER: 
Xuekui Xia
PROVIDER: PXD031893 | iProX | Fri Feb 25 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
Investigation of chetomin as a lead compound and its biosynthetic pathway.
Zhao Peipei P Liu Hairong H Wu Qinghua Q Meng Qingzhou Q Qu Kunyu K Yin Xin X Wang Mengmeng M Zhao Xiangxiang X Qi Jun J Meng Yiwei Y Xia Xuekui X Zhang Lixin L
Applied microbiology and biotechnology 20220426 8
Chaetomium fungi produce a diversity of bioactive compounds. Chaetomium cochliodes SD-280 possesses 91 secondary metabolite gene clusters and exhibits strong antibacterial activity. One of the active compounds responsible for that activity, chetomin, has a minimum inhibitory concentration (MIC) for anti-methicillin-resistant Staphylococcus aureus (MRSA) of 0.05 μg/mL (vancomycin: 0.625 μg/mL). This study demonstrated that the addition of glutathione (GSH) can enhance chetomin yield dramatically, ...[more]
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