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Milk exosome delivery anti-cancer drugs

ABSTRACT: The protein of milk exosomes help the deliver efficiency

ORGANISM(S): Sus Scrofa Domesticus

SUBMITTER: Jingxin Ding

PROVIDER: PXD032682 | iProX | Mon Mar 21 00:00:00 GMT 2022

REPOSITORIES: iProX

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Exosome Mediated Cytosolic Cisplatin Delivery Through Clathrin-Independent Endocytosis and Enhanced Anti-cancer Effect <i>via</i> Avoiding Endosome Trapping in Cisplatin-Resistant Ovarian Cancer.

Zhou Guannan G Gu Yuanyuan Y Zhu Zhongyi Z Zhang Hongdao H Liu Wei W Xu Beiying B Zhou Fangyue F Zhang Menglei M Hua Keqin K Wu Ligang L Ding Jingxin J

Frontiers in medicine 20220503

<h4>Background</h4>Ovarian carcinoma is one of the most common gynecologic malignancies, cisplatin resistance has become a key obstacle to the successful treatment of ovarian cancer because ovarian carcinomas are liable to drug resistance. To find an effective drug carrier is an urgent need.<h4>Methods</h4>Exosomes and loading-cisplatin exosomes are isolated using differential centrifugation and characterized by transmission, electron, nanoparticle tracking analysis. The anti-cancer effect of ci ...[more]

PMID: 35592860

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