Integrated Proteogenomic Characterization of Medullary Thyroid Carcinoma
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Wenjun Wei
PROVIDER: PXD032887 | iProX | Fri Apr 01 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
Integrated proteogenomic characterization of medullary thyroid carcinoma.
Shi Xiao X Sun Yaoting Y Shen Cenkai C Zhang Yan Y Shi Rongliang R Zhang Fan F Liao Tian T Lv Guojun G Zhu Zhengcai Z Jiao Lianghe L Li Peng P Xu Tiansheng T Qu Ning N Huang Naisi N Hu Jiaqian J Zhang Tingting T Gu Yanzi Y Qin Guangqi G Guan Haixia H Pu Weilin W Li Yuan Y Geng Xiang X Zhang Yan Y Chen Tongzhen T Huang Shenglin S Zhang Zhikang Z Ge Shuting S Wang Wu W Xu Weibo W Yu Pengcheng P Lu Zhongwu Z Wang Yulong Y Guo Liang L Wang Yu Y Guo Tiannan T Ji Qinghai Q Wei Wenjun W
Cell discovery 20221108 1
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy derived from parafollicular cells (C cells) of the thyroid. Here we presented a comprehensive multi-omics landscape of 102 MTCs through whole-exome sequencing, RNA sequencing, DNA methylation array, proteomic and phosphoproteomic profiling. Integrated analyses identified BRAF and NF1 as novel driver genes in addition to the well-characterized RET and RAS proto-oncogenes. Proteome-based stratification of MTCs revealed three mol ...[more]
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