USP14 Promotes Tryptophan Metabolism and Immune Suppression by Stabilizing IDO1 in Colorectal Cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Wenting Liao
PROVIDER: PXD033718 | iProX | Thu May 05 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer.
Shi Dongni D Wu Xianqiu X Jian Yunting Y Wang Junye J Huang Chengmei C Mo Shuang S Li Yue Y Li Fengtian F Zhang Chao C Zhang Dongsheng D Zhang Huizhong H Huang Huilin H Chen Xin X Wang Y Alan YA Lin Chuyong C Liu Guozhen G Song Libing L Liao Wenting W
Nature communications 20220926 1
Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR). Here, we show a post-transcriptional regulatory mechanism of IDO1 regulated by a proteasome-associated deubiquitinating enzyme, USP14, in colorectal cancer (CRC). Overexpression of USP14 promotes tryptophan metabolism and T-cell dysfunction by stabi ...[more]
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