CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3β/β-catenin pathway
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Liansheng Wang
PROVIDER: PXD035187 | iProX | Sat Jul 09 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3β/β-catenin pathway.
Sun Jiateng J Yang Tongtong T Wei Tianwen T Zhou Liuhua L Shan Tiankai T Chen Jiawen J Gu Lingfeng L Chen Bingrui B Liu Liu L Jiang Qiqi Q Du Chong C Ma Yao Y Wang Hao H Chen Feng F Guo Xuejiang X Ji Yong Y Wang Liansheng L
Frontiers in cardiovascular medicine 20220823
The mammalian heart possesses entire regeneration capacity after birth, which is lost in adulthood. The role of the kinase network in myocardial regeneration remains largely elusive. SGK3 (threonine-protein kinase 3) is a functional kinase we identified previously with the capacity to promote cardiomyocyte proliferation and cardiac repair after myocardial infarction. However, the upstream signals regulating SGK3 are still unknown. Based on the quantitative phosphoproteomics data and pulldown ass ...[more]
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