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Proteomic analysis reveal pharmacological mechanism of Xueshuantong injection on preventing early acute myocardial infarction injury

ABSTRACT: This study was designed to investigate the efficacy and mechanism of XST in alleviating hyperacute myocardial infarction injury in rats. In addition, differential proteomics was used to explore the target protein of XST, and combined with bioinformatics analysis, the possible biological basis of its therapeutic effect was discussed.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jianxun Liu

PROVIDER: PXD035370 | iProX | Fri Jul 15 00:00:00 BST 2022

REPOSITORIES: iProX

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Proteomic analysis revealed the pharmacological mechanism of Xueshuantong injection in preventing early acute myocardial infarction injury.

Wang Aoao A Li Ying Y Wang Ziyan Z Xin Gaojie G You Yue Y Sun Mingqian M Miao Lan L Li Lei L Pan Yinghong Y Liu Jianxun J

Frontiers in pharmacology 20221221

Background: Acute myocardial infarction (AMI) is a common and life-threatening cardiovascular disease. However, there is a lack of pathology and drug studies on AMI within 20 min. Xueshuantong injection (XST) is mainly composed of Panax notoginseng saponins, which can dilate blood vessels and improve blood circulation, and is clinically used in the treatment of cardiovascular and cerebrovascular diseases. Purpose: The study aimed to investigate the protective mechanism of Xu ...[more]

PMID: 36618918

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