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MS analysis of human TFEB posttranslational modification

ABSTRACT: Mass spectrometry analysis of TFEB acetylation, phosphorylation, and ubiquitination without or with TSA treatment

ORGANISM(S): Homo Sapiens

SUBMITTER: Yang Li

PROVIDER: PXD035879 | iProX | Mon Aug 08 00:00:00 BST 2022

REPOSITORIES: iProX

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TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice.

Li Tianyou T Yin Limin L Kang Xinyi X Xue Wenlong W Wang Ning N Zhang Jie J Yuan Ping P Lin Lingxi L Li Yang Y

The Journal of biological chemistry 20221027 12

Lysosomes are one of the major centers for regulating cargo degradation and protein quality control. Transcription factor EB (TFEB)-promoted lysosome biogenesis enhances lysosome-mediated degradation and alleviates neurodegenerative diseases, but the mechanisms underlying TFEB modification and activation are still poorly understood. Here, we report essential roles of TFEB acetylation in TFEB nuclear translocation and lysosome biogenesis, which are independent of TFEB dephosphorylation. By screen ...[more]

PMID: 36441024

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