Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Zhiqiang Xiao
PROVIDER: PXD036235 | iProX | Tue Aug 23 00:00:00 BST 2022
REPOSITORIES: iProX
Xiao Ding D Zeng Ting T Zhu Wei W Yu Zheng-Zheng ZZ Huang Wei W Yi Hong H Lu Shan-Shan SS Feng Juan J Feng Xue-Ping XP Wu Di D Wen Qi Q Zhou Jian-Hua JH Yuan Li L Zhuang Wei W Xiao Zhi-Qiang ZQ
Cancer immunology research 20231001 10
The deregulation of Annexin A1 (ANXA1), a regulator of inflammation and immunity, leads to cancer growth and metastasis. However, whether ANXA1 is involved in cancer immunosuppression is still unclear. Here, we report that ANXA1 knockdown (i) dramatically downregulates programmed cell death-ligand 1 (PD-L1) expression in breast cancer, lung cancer, and melanoma cells; (ii) promotes T cell-mediated killing of cancer cells in vitro; and (iii) inhibits cancer immune escape in immune-competent mice ...[more]