Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Zhiyong Mao
PROVIDER: PXD036308 | iProX | Thu Aug 25 00:00:00 BST 2022
REPOSITORIES: iProX
Zhang Weina W Wang Mingzhu M Song Zhiwei Z Fu Qianzheng Q Chen Jiayu J Zhang Weitao W Gao Shuai S Sun Xiaoxiang X Yang Guang G Zhang Qiang Q Yang Jiaqing J Tang Huanyin H Wang Haiyan H Kou Xiaochen X Wang Hong H Mao Zhiyong Z Xu Xiaojun X Gao Shaorong S Jiang Ying Y
Nature communications 20230403 1
Farrerol, a natural flavanone, promotes homologous recombination (HR) repair to improve genome-editing efficiency, but the specific protein that farrerol directly targets to regulate HR repair and the underlying molecular mechanisms have not been determined. Here, we find that the deubiquitinase UCHL3 is the direct target of farrerol. Mechanistically, farrerol enhanced the deubiquitinase activity of UCHL3 to promote RAD51 deubiquitination, thereby improving HR repair. Importantly, we find that e ...[more]