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Arabidopsis γ-H2A.X-INTERACTING PROTEIN participates in DNA damage response and safeguards chromatin stability

ABSTRACT: We extracted proteins from WT and xip for phospho-peptide enrichment and employed a quantitative phospho-proteomics approach to systematically survey the relevant modification changes.

ORGANISM(S): Arabidopsis Thaliana

SUBMITTER: Yan Zhu

PROVIDER: PXD037072 | iProX | Wed Sep 28 00:00:00 BST 2022

REPOSITORIES: iProX

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Arabidopsis γ-H2A.X-INTERACTING PROTEIN participates in DNA damage response and safeguards chromatin stability.

Fan Tianyi T Kang Huijia H Wu Di D Zhu Xinyu X Huang Lin L Wu Jiabing J Zhu Yan Y

Nature communications 20221226 1

Upon the occurrence of DNA double strand breaks (DSB), the proximal histone variant H2A.X is phosphorylated as γ-H2A.X, a critical signal for consequent DSB signaling and repair pathways. Although γ-H2A.X-triggered DNA damage response (DDR) has been well-characterized in yeast and animals, the corresponding pathways in plant DDR are less well understood. Here, we show that an Arabidopsis protein γ-H2A.X-INTERACTING PROTEIN (XIP) can interact with γ-H2A.X. Its C-terminal dual-BRCT-like domain con ...[more]

PMID: 36572675

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