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Identification of an unrecognized circRNA associated with the development of renal fibrosis

ABSTRACT: In the current study, the RF model of the rat was established, and RNA-sequencing and real-time polymerase chain reaction (qRT-PCR) experiments were implemented. Subsequently, cell apoptosis and proliferation were carried out. Finally, the iTRAQ proteomics analyses were carried out for the samples.

ORGANISM(S): Homo Sapiens

SUBMITTER: Cuie Li

PROVIDER: PXD037827 | iProX | Mon Oct 31 00:00:00 GMT 2022

REPOSITORIES: iProX

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Identification of an unrecognized circRNA associated with development of renal fibrosis.

Zhu Yun Y Yan Weimin W Xu Shuangyan S Yu Xiaochao X Sun Shuo S Zhang Shaoxiong S Zhao Ran R Tao Jiayue J Li Yunwei Y Li Cuie C

Frontiers in genetics 20230104

<b>Backgroud:</b> Renal fibrosis is the common characteristic of chronic kidney disease. Circular RNA plays an essential role in the occurrence and development of Renal fibrosis, but its regulative mechanism remains elusive. <b>Methods:</b> The animal and cell model of Renal fibrosis was established, and RNA-sequencing and real-time polymerase chain reaction (qRT-PCR) experiments were implemented. Subsequently, experiments for detecting apoptosis and proliferation of cell, were carried out, and ...[more]

PMID: 36685959

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