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Analysis of the structure of the MTA1 complex using chemical cross-linking mass spectrometry

ABSTRACT: Analysis of the structure of the MTA1 complex using chemical cross-linking mass spectrometry

ORGANISM(S): Tetrahymena Thermophila Sb210

SUBMITTER: Ping Yin

PROVIDER: PXD038459 | iProX | Wed Nov 30 00:00:00 GMT 2022

REPOSITORIES: iProX

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Structural insights into DNA N<sup>6</sup>-adenine methylation by the MTA1 complex.

Yan Junjun J Liu Feiqing F Guan Zeyuan Z Yan Xuhui X Jin Xiaohuan X Wang Qiang Q Wang Zican Z Yan Junjie J Zhang Delin D Liu Zhu Z Wu Shan S Yin Ping P

Cell discovery 20230120 1

N<sup>6</sup>-methyldeoxyadenine (6mA) has recently been reported as a prevalent DNA modification in eukaryotes. The Tetrahymena thermophila MTA1 complex consisting of four subunits, namely MTA1, MTA9, p1, and p2, is the first identified eukaryotic 6mA methyltransferase (MTase) complex. Unlike the prokaryotic 6mA MTases which have been biochemically and structurally characterized, the operation mode of the MTA1 complex remains largely elusive. Here, we report the cryogenic electron microscopy st ...[more]

PMID: 36658132

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