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Proteomics comparison of protein changes in two well-established animal pain models of chronic pain using wild-type and Nav1.8 knockout mice

ABSTRACT: Isobaric tags for relative and absolute quantitation -based proteomics analysis was performed to profile changes in the abundance of spinal cord proteins in two well-established animal pain models of chronic pain using wild-type and Nav1.8 knockout mice

ORGANISM(S): Mus <genus>

SUBMITTER: Guangyou Duan

PROVIDER: PXD042455 | iProX | Wed May 24 00:00:00 BST 2023

REPOSITORIES: iProX

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A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain.

Liu Baowen B Wu Wenyao W Cui LingLing L Zheng Xuemei X Li Ningbo N Zhang Xianwei X Duan Guangyou G

iScience 20230528 6

Previous studies validate that inhibiting sodium channel 1.8 (Nav1.8) effectively relieves inflammatory and neuropathic pain. However, Nav1.8 blockers have cardiac side effects in addition to analgesic effects. Here, we constructed a spinal differential protein expression profile using Nav1.8 knockout mice to screen common downstream proteins of Nav1.8 in inflammatory and neuropathic pain. We found that aminoacylase 1 (ACY1) expression was increased in wild-type mice compared to Nav1.8 knockout ...[more]

PMID: 37378314

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