Proteomics

Dataset Information

0

To explore potential proteins that bind to usp16

ABSTRACT: HEK293T cells were transfected with FLag-USP16, and cells were performed with co-immunoprecipitation by Flag antibody or IgG with protein A/G beads.

ORGANISM(S): Homo Sapiens

SUBMITTER: Gaozan Tong  

PROVIDER: PXD045021 | iProX | Fri Sep 01 00:00:00 BST 2023

REPOSITORIES: iProX

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Publications

FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.

Tong Gaozan G   Chen Yiming Y   Chen Xixi X   Fan Junfu J   Zhu Kunxuan K   Hu ZiJing Z   Li Santie S   Zhu Junjie J   Feng Jianjun J   Wu Zhaohang Z   Hu Zhenyu Z   Zhou Bin B   Jin Litai L   Chen Hui H   Shen Jingling J   Cong Weitao W   Li XiaoKun X  

Nature communications 20230930 1

Hepatic ischemia-reperfusion injury (IRI) is a common complication occurs during hepatic resection and transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Here, we aim to explore the role of fibroblast growth factor 18 (FGF18) in hepatic IRI. In this work, we find that Hepatic stellate cells (HSCs) secrete FGF18 and alleviates hepatocytes injury. HSCs-specific FGF18 deletion largely aggravates hepatic IRI. Mechanistically, FGF18 treatment reduces the l  ...[more]