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Proteomics of male reproduction

ABSTRACT: To investigate the important function of membrane protein TMEM225 in sperm, we constructed Tmem225 knockout mice. Sperm from knockout mice and control mice were isolated for proteomic analysis.

ORGANISM(S): Mus Musculus

SUBMITTER: Jiali Liu

PROVIDER: PXD046484 | iProX | Thu Jan 18 00:00:00 GMT 2024

REPOSITORIES: iProX

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TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice.

Lv Zheng Z Sun Longjie L Xie Xiaomei X Yao Xiaohong X Tian Shuang S Wang Chaofan C Wang Fengchao F Liu Jiali J

Molecular & cellular proteomics : MCP 20240120 2

Nonobstructive azoospermia is the leading cause of male infertility. Abnormal levels of transmembrane protein 225 (TMEM225), a testis-specific protein, have been found in patients with nonobstructive azoospermia, suggesting that TMEM225 plays an essential role in male fertility. Here, we generated a Tmem225 KO mouse model to explore the function and mechanism of TMEM225 in male reproduction. Male Tmem225 KO mice were infertile. Surprisingly, Tmem225 deletion did not affect spermatogenesis, but T ...[more]

PMID: 38246484

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