Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Xiong Ji
PROVIDER: PXD048023 | iProX | Tue May 28 00:00:00 BST 2024
REPOSITORIES: iProX
Bao Lijun L Zhu Junyi J Shi Tingxin T Jiang Yongpeng Y Li Boyuan B Huang Jie J Ji Xiong X
Nucleic acids research 20240801 14
RNA polymerase II drives mRNA gene expression, yet our understanding of Pol II degradation is limited. Using auxin-inducible degron, we degraded Pol II's RPB1 subunit, resulting in global repression. Surprisingly, certain genes exhibited increased RNA levels post-degradation. These genes are associated with GPCR ligand binding and are characterized by being less paused and comprising polycomb-bound short genes. RPB1 degradation globally increased KDM6B binding, which was insufficient to explain ...[more]