Palmitoylation licenses RIPK1 cytotoxicity in the TNF pathway
Ontology highlight
ABSTRACT: We identified S-palmitoylation as a licensing modification for RIPK1 kinase activity in the TNF pathway. We found that DHHC5 palmitoylates RIPK1 at Cys257 residue, a process dependent on K63-linked ubiquitination of RIPK1, in response to TNF stimulation.
ORGANISM(S): Mus Musculus
SUBMITTER:
Daichao Xu
PROVIDER: PXD050636 | iProX | Fri Mar 15 00:00:00 GMT 2024
REPOSITORIES: iProX
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