Dataset Information
E. coli wt/delta L31, SWATH, rep3
Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia Coli
SUBMITTER: Hideki Taguchi
PROVIDER: PXD007808 | JPOST Repository | Sun Nov 05 00:00:00 GMT 2017
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| dL31_delta_S1.wiff | Wiff | |||
| dL31_delta_S1.wiff.scan | Wiff | |||
| dL31_delta_S2.wiff | Wiff | |||
| dL31_delta_S2.wiff.scan | Wiff | |||
| dL31_delta_S3.wiff | Wiff |
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Publications
Intrinsic Ribosome Destabilization Underlies Translation and Provides an Organism with a Strategy of Environmental Sensing.
Molecular cell 20171101 3
Nascent polypeptides can modulate the polypeptide elongation speed on the ribosome. Here, we show that nascent chains can even destabilize the translating Escherichia coli ribosome from within. This phenomenon, termed intrinsic ribosome destabilization (IRD), occurs in response to a special amino acid sequence of the nascent chain, without involving the release or the recycling factors. Typically, a consecutive array of acidic residues and those intermitted by alternating prolines induce IRD. Th ...[more]
