Ontology highlight
ABSTRACT:
ORGANISM(S): None
SUBMITTER: Shigeru Shibata
PROVIDER: PXD010048 | JPOST Repository | Tue Jul 17 00:00:00 BST 2018
REPOSITORIES: jPOST
Cell reports 20180701 3
Mineralocorticoid receptor (MR) signaling regulates both renal Na-Cl reabsorption and K<sup>+</sup> excretion. We previously demonstrated that phosphorylation of S843 in the MR ligand-binding domain in renal intercalated cells is involved in the balance of these activities by regulating ligand binding and signaling. However, the kinase that phosphorylates MR<sup>S843</sup> is unknown. Using a high-throughput screen assay of 197 kinases, we found that ULK1 is the principal kinase that is responsi ...[more]