Dataset Information
KSN01_Proteome_CellLine: Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Akira Nishiyama
PROVIDER: PXD010107 | JPOST Repository | Tue Dec 15 00:00:00 GMT 2020
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20170630_58_Kagawa_cont_1_5uL.raw | Raw | |||
| 20170630_62_Kagawa_cont_2_5uL.raw | Raw | |||
| 20170630_66_Kagawa_cont_3_5uL.raw | Raw | |||
| 20170630_70_Kagawa_cont_4_5uL.raw | Raw | |||
| 20170630_74_Kagawa_cont_5_5uL.raw | Raw |
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Publications
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H.
Communications biology 20201127 1
(Pro)renin receptor [(P)RR] has a role in various diseases, such as cardiovascular and renal disorders and cancer. Aberrant (P)RR expression is prevalent in pancreatic ductal adenocarcinoma (PDAC) which is the most common pancreatic cancer. Here we show whether aberrant expression of (P)RR directly leads to genomic instability in human pancreatic ductal epithelial (HPDE) cells. (P)RR-expressing HPDE cells show obvious cellular atypia. Whole genome sequencing reveals that aberrant (P)RR expressio ...[more]
