Proteomics

Dataset Information

0

Tumor and adjacent normal tissue

ABSTRACT: Proteome characterization of 5 breast tumors and adjacent normal tissue using HiRIEF nanoLC-MS/MS.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Janne Lehtiö 

PROVIDER: PXD011385 | JPOST Repository | Mon Feb 04 00:00:00 GMT 2019

REPOSITORIES: jPOST

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HJ_QEHF_20161223_BC_NvsT_TMT10_200ug_IPG3p7-4p9_7of15ul_fr01.raw Raw
HJ_QEHF_20161223_BC_NvsT_TMT10_200ug_IPG3p7-4p9_7of15ul_fr02.raw Raw
HJ_QEHF_20161223_BC_NvsT_TMT10_200ug_IPG3p7-4p9_7of15ul_fr03.raw Raw
HJ_QEHF_20161223_BC_NvsT_TMT10_200ug_IPG3p7-4p9_7of15ul_fr04.raw Raw
HJ_QEHF_20161223_BC_NvsT_TMT10_200ug_IPG3p7-4p9_7of15ul_fr05.raw Raw
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Publications

Breast cancer quantitative proteome and proteogenomic landscape.

Johansson Henrik J HJ   Socciarelli Fabio F   Vacanti Nathaniel M NM   Haugen Mads H MH   Zhu Yafeng Y   Siavelis Ioannis I   Fernandez-Woodbridge Alejandro A   Aure Miriam R MR   Sennblad Bengt B   Vesterlund Mattias M   Branca Rui M RM   Orre Lukas M LM   Huss Mikael M   Fredlund Erik E   Beraki Elsa E   Garred Øystein Ø   Boekel Jorrit J   Sauer Torill T   Zhao Wei W   Nord Silje S   Höglander Elen K EK   Jans Daniel C DC   Brismar Hjalmar H   Haukaas Tonje H TH   Bathen Tone F TF   Schlichting Ellen E   Naume Bjørn B   Luders Torben T   Borgen Elin E   Kristensen Vessela N VN   Russnes Hege G HG   Lingjærde Ole Christian OC   Mills Gordon B GB   Sahlberg Kristine K KK   Børresen-Dale Anne-Lise AL   Lehtiö Janne J  

Nature communications 20190408 1

In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins quantified across all tumors, for the first time recapitulates BC subtypes. Additionally, poor-prognosis basal-like and luminal B tumors are further subdivided by immune component infiltration, suggesting the current classification is incomplete. Proteome-based networks distingu  ...[more]

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