Dataset Information

AGE-modification sites of human CRMP2 in vitro

ABSTRACT: AGE-modification sites of human recombinant CRMP2 (1-532) in vitro under enhanced carbonyl stress

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Nobutaka Hirokawa

PROVIDER: PXD013522 | JPOST Repository | Tue Oct 01 00:00:00 BST 2019

REPOSITORIES: jPOST

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Dataset's files

Source:

			Action	DRS
	180704_QE2_058_Toyoshima_01_0613-1_GRT.raw	Raw
	180704_QE2_058_Toyoshima_01_0613-1_MS.raw	Raw
	in-vitro_180704_QE2_058_Toyoshima_01_0613-1_GRT_sequestHT_Guest-onlyDPYL2_protein(g)_peptide(g)_seqHTmed.xlsx	Xlsx
	in-vitro_180704_QE2_058_Toyoshima_01_0613-1_MS_sequestHT_Guest-onlyDPYL2_protein(g)_peptide(g)_seqHTmed.xlsx	Xlsx

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Publications

Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.

Toyoshima Manabu M Jiang Xuguang X Ogawa Tadayuki T Ohnishi Tetsuo T Yoshihara Shogo S Balan Shabeesh S Yoshikawa Takeo T Hirokawa Nobutaka N

Life science alliance 20191007 5

Enhanced carbonyl stress underlies a subset of schizophrenia, but its causal effects remain elusive. Here, we elucidated the molecular mechanism underlying the effects of carbonyl stress in iPS cells in which the gene encoding zinc metalloenzyme glyoxalase I (<i>GLO1</i>), a crucial enzyme for the clearance of carbonyl stress, was disrupted. The iPS cells exhibited significant cellular and developmental deficits, and hyper-carbonylation of collapsing response mediator protein 2 (CRMP2). Structur ...[more]

PMID: 31591136

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