Proteomics

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Proteomics data of mouse skeletal muscles (hypergravity exposure)

ABSTRACT: This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as osteoporosis occurring on the ground by searching serum, bone and skeletal muscle (soleus, extensor digitorum longus) proteomes. The goal of this study is to get better understanding to protect the health of both astronauts and osteoporosis patients. Proteome analyses of skeletal muscles from 10 male C57BL/6J mouse (1-g gravity and 3-g gravity [n=5, respectively]) were carried out tryptic digestion followed by LC-MS/MS analysis (DDA). The obtained results were searched against UniProt DB by Mascot, and the identified peptides were filtered at 1% FDR threshold by searching against the randomized decoy DB.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Hisashi Hirano 

PROVIDER: PXD017240 | JPOST Repository | Thu Feb 20 00:00:00 GMT 2020

REPOSITORIES: jPOST

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Dataset's files

Source:
Action DRS
170626Elite_Sol_10.raw Raw
170626Elite_Sol_11.raw Raw
170626Elite_Sol_12.raw Raw
170626Elite_Sol_2.raw Raw
170626Elite_Sol_3.raw Raw
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Publications

Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice.

Ohira Takashi T   Ino Yoko Y   Nakai Yusuke Y   Morita Hironobu H   Kimura Ayuko A   Kurata Yoichi Y   Kagawa Hiroyuki H   Kimura Mitsuo M   Egashira Kenji K   Moriya Shunsuke S   Hiramatsu Kyoko K   Kawakita Masao M   Kimura Yayoi Y   Hirano Hisashi H  

Journal of proteomics 20200212

Investigating protein abundance profiles is important to understand the differences in the slow and fast skeletal muscle characteristics. The profiles in soleus (Sol) and extensor digitorum longus (EDL) muscles in mice exposed to 1 g or 3 g for 28 d were compared. The biological implications of the profiles revealed that hypergravity exposure activated a larger number of pathways involved in protein synthesis in Sol. In contrast, the inactivation of signalling pathways involved in oxidative phos  ...[more]

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