Dataset Information
KT01_b: The Bartonella autotransporter BafA mimics host VEGF to drive angiogenesis. Wild type.
Ontology highlight
ABSTRACT:
ORGANISM(S): Bartonella Henselae Str. Houston-1
SUBMITTER: Kentaro Tsukamoto
PROVIDER: PXD018354 | JPOST Repository | Wed Jun 10 00:00:00 BST 2020
REPOSITORIES: jPOST
Dataset's files
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Publications
The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis.
Nature communications 20200716 1
Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. The underlying mechanisms are unclear, but involve secretion of an unidentified mitogenic factor. Here, we use functional transposon-mutant screening in Bartonella henselae to identify such factor as a pro-angiogenic autotransporter, called BafA. The passenger domain of BafA induces cell proliferation, tube formation and sprouting of microvessels, and drives angiogenesis in mice. BafA interacts wit ...[more]
