Dataset Information

Bovine Respiratory Disease Complex

ABSTRACT: Bovine respiratory epithelial cells have different susceptibility to bovine respiratory syncytial virus infection. The cells derived from the lower respiratory tract were significantly more susceptible to the virus than those derived from the upper respiratory tract. Pre-infection with virus of lower respiratory tract with increased adherence of P. multocida; this was not the case for upper tract. However, the molecular mechanisms of enhanced bacterial adherence are not completely understood. To investigate whether virus infection regulates the cellular adherence receptor on bovine trachea-, bronchus- and lung-epithelial cells, we performed proteomic analyses.

ORGANISM(S): Bos Taurus

SUBMITTER: Tamaki Okabayashi

PROVIDER: PXD019509 | JPOST Repository | Tue Jul 28 00:00:00 BST 2020

REPOSITORIES: jPOST

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Dataset's files

Source:

			Action	DRS
	1.submit%20protein%20bTEC-BRSV.xlsx	Xlsx
	2.submit%20protein%20bBEC-BRSV.xlsx	Xlsx
	20190806_1_bLEC-_1.raw	Raw
	20190806_1_bLEC-_2.raw	Raw
	20190806_1_bLEC-_3.raw	Raw

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Publications

Bovine Respiratory Syncytial Virus Decreased Pasteurella multocida Adherence by Downregulating the Expression of Intercellular Adhesion Molecule-1 on the Surface of Upper Respiratory Epithelial Cells.

Sudaryatma Putu Eka PE Saito Akatsuki A Mekata Hirohisa H Kubo Meiko M Fahkrajang Watcharapong W Okabayashi Tamaki T

Veterinary microbiology 20200602

The synergistic infection of bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) may predispose cattle to develop severe pneumonia. Previously, we reported that BRSV infection significantly decreased PM adherence to the upper respiratory epithelial cells. It may allow bacteria to invade into the lower respiratory tract and lead to severe pneumonia. To investigate whether BRSV infection regulates the cell surface adherence receptor on bovine trachea epithelial cells (bTECs), ...[more]

PMID: 32605748

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