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Proteome analysis of BMPR2 mutation PASMCs

ABSTRACT: Proteome analysis of BMPR2 mutation PASMCs with or without PERK knockout under hypoxia.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Takashi Shimizu

PROVIDER: PXD020182 | JPOST Repository | Sat Jul 03 00:00:00 BST 2021

REPOSITORIES: jPOST

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PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by <i>BMPR2</i> mutation.

Shimizu Takashi T Higashijima Yoshiki Y Kanki Yasuharu Y Nakaki Ryo R Kawamura Takeshi T Urade Yoshihiro Y Wada Youichiro Y

Science signaling 20210126 667

Pulmonary arterial hypertension (PAH) is a fatal disease characterized by excessive pulmonary vascular remodeling. However, despite advances in therapeutic strategies, patients with PAH bearing mutations in the bone morphogenetic protein receptor type 2 (<i>BMPR2</i>)-encoding gene present severe phenotypes and outcomes. We sought to investigate the effect of PER-like kinase (PERK), which participates in one of three major pathways associated with the unfolded protein response (UPR), on PAH path ...[more]

PMID: 33500333

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