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MEAF6 is essential for proliferation and plays a role in the assembly of KAT7 complexes

ABSTRACT: MEAF6 is essential for proliferation and plays a role in the assembly of KAT7 complexes.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Hitoshi Niwa

PROVIDER: PXD020422 | JPOST Repository | Wed Sep 23 00:00:00 BST 2020

REPOSITORIES: jPOST

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MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.

Matsuura Kumi K Tani Naoki N Usuki Shingo S Torikai-Nishikawa Satomi S Okano Masaki M Niwa Hitoshi H

Experimental cell research 20200909 1

Myst family genes encode lysine acetyltransferases that mainly mediate histone acetylation to control transcription, DNA replication and DNA damage response. They form tetrameric complexes with PHD-finger proteins (Brpfs or Jades) and small non-catalytic subunits Ing4/5 and Meaf6. Although all the components of the complex are well-conserved from yeast to mammals, the function of Meaf6 and its homologs has not been elucidated in any species. Here we revealed the role of Meaf6 utilizing inducible ...[more]

PMID: 32918898

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