Proteomics

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Mitochondrial proteome of human leuekmia.

ABSTRACT: Proteome characterization of isolated mitochondria samples prepared from three commonly used acute leukemia cell lines (HL-60, KG-1, MV-4-11). Data were compared to isolated mitochondria prepared from peripheral blood mononuclear cells (PBMC), isolated from healthy human subjects.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Kelsey Fisher-Wellman 

PROVIDER: PXD020715 | JPOST Repository | Tue Aug 04 00:00:00 BST 2020

REPOSITORIES: jPOST

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KFW1.raw Raw
KFW10.raw Raw
KFW11.raw Raw
KFW12.raw Raw
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Publications

Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful 'mito-therapeutics' cannot discriminate cancerous from non-cancerous OXPHOS and thus suffer from a limited therapeutic index. Using acute myeloid leukemia (AML) as a model, herein, we leveraged an in-house diagnostic biochemical workflow to identify 'actionable' bioenergetic vulnerabilities intrinsic to canc  ...[more]

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